Bifidobacterium bifidum and Reduced Kidney Fibrosis

• ILA-producing bifidobacterium bifidum ameliorates chronic kidney disease via AHR signaling by modulating the gut-kidney axis.

  • 2026-04
  • Food research international (Ottawa, Ont.) 230
  • • Qinglian Hua
    • Yang Meng
    • Jinpeng Hu
    • Yanchen Wei
    • Huaxi Yi
    • Xi Liang
    • Lanwei Zhang
    • Zhe Zhang

  • PubMed: 41794500
  • DOI: 10.1016/j.foodres.2026.118638

  4 Insights on

  • Reduced Kidney Fibrosis

  • Low evidence
  • Animal Study

  ILA exerts its effects by activating the aryl hydrocarbon receptor (AHR) signaling pathway, which in turn inhibits NLRP3 inflammasome activation, thereby achieving the dual benefit of mitigating intestinal inflammation and alleviating renal fibrosis.

  Effect

  Beneficial

  Effect size

  Moderate