Bifidobacterium breve Bb-18 and Increased Butyrate Production

• Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial.

  • 2025-08-23
  • RCT
  • Nutrients 17(17)
  • • Brooke A Napier
    • Jessica R Allegretti
    • Paul Feuerstadt
    • Colleen R Kelly
    • Nicholas W Van Hise
    • Ralf Jäger
    • Zain Kassam
    • Gregor Reid

  • PubMed: 40944126
  • DOI: 10.3390/nu17172734

  2 Insights on

  • Increased Butyrate Production

  • High evidence
  • Rigorous Journal

  The synbiotic also significantly increased fecal butyrate levels (p < 0.03), and butyrate-producing species, in low-baseline butyrate producers, through Day 91.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes