Bifidobacterium breve Bb-18 and Modified Fetal Brain Metabolism

• Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice.

  • 2024-10
  • Molecular metabolism 88
  • • Jorge Lopez-Tello
    • Raymond Kiu
    • Zoe Schofield
    • Cindy X W Zhang
    • Douwe van Sinderen
    • Gwénaëlle Le Gall
    • Lindsay J Hall
    • Amanda N Sferruzzi-Perri

  • PubMed: 39127167
  • DOI: 10.1016/j.molmet.2024.102004

  1 Insight on

  • Modified Fetal Brain Metabolism

  • Low evidence
  • Animal Study

  Maternal colonization with B. breve resulted in significant metabolic changes in the fetal brain. Specifically, ten metabolites, including citrate, 3-hydroxyisobutyrate, and carnitine, were reduced in the fetal brain.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes