Bifidobacterium breve Bb-18 and Reduced Gastrointestinal Adverse Events

• Interventions Targeting the Gut Microbiome to Improve Cancer Treatment Outcomes and Their Gastrointestinal Side Effects: A Systematic Review and Meta-analysis.

  • 2026-02
  • Meta-Analysis · n = 37
  • The Journal of nutrition 156(2)
  • • Cecilia Morel
    • Ruijie Li
    • Carmen Fiuza Luces
    • Mark Fh Brougham
    • Juan Francisco Pascual-Gazquez
    • Luciana Torquati
    • Raquel Revuelta Iniesta

  • PubMed: 41475679
  • DOI: 10.1016/j.tjnut.2025.101300

  4 Insights on

  • Reduced Gastrointestinal Adverse Events

  • High evidence

  GM interventions reduced the overall risk of GIAEs [relative risk (RR): 0.59; 95% CI: 0.53, 0.65; I2: 76.8%; 95% prediction interval (PI): 0.32, 1.08], including diarrhea, constipation, nausea, and vomiting

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes