Efficacy and safety of probiotics in preventing chemotherapy-related diarrhea in patients with colorectal cancer: A systematic review and meta-analysis based on 18 randomized trials.
- 2025-07-04
- Meta-Analysis · n = 1,526
- Medicine 104(27)
- Meilin Yang
- Lu Wang
- Chu Luo
- Jiarong Shang
- Xia Zheng
- Jun Qian
- Ran Yang
- PubMed: 40629588
- DOI: 10.1097/md.0000000000043126
- High evidence
Meta-analysis demonstrated that probiotics significantly reduced the incidence of diarrhea following chemotherapy in the probiotic group compared to the control group (risk ratio, 0.51; 95% confidence interval: [0.40-0.64]; P = .029).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes