Bifidobacterium breve MAK40B22B and Improved Synaptic Plasticity

• Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome

  • 2021-05-11
  • Clinical Trial
  • Nutrients 13(5)
  • • G. Zhu
    • Jianxin Zhao
    • Hao Zhang
    • Wei Chen
    • Gang Wang

  • PubMed: 34064762
  • DOI: 10.3390/nu13051602

  11 Insights on

  • Improved Synaptic Plasticity

  • Low evidence
  • Animal Study

  *Bifidobacterium breve* CCFM1025 and WX treatment significantly improved synaptic plasticity and increased the concentrations of brain-derived neurotrophic factor (BDNF), fibronectin type III domain-containing protein 5 (FNDC5), and postsynaptic density protein 95 (PSD-95).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes