Bifidobacterium breve and Improved Response to PD-1 Immunotherapy

• Bifidobacterium breve inhibits colorectal cancer via extracellular vesicles containing formate acetyltransferase.

  • 2026-03-16
  • Journal of nanobiotechnology 24(1)
  • • Yuefeng Zhang
    • Qian Zhang
    • Yue Luo
    • Xiaohan Li
    • Ruirui Zhao
    • Yaning Xu
    • Saixuan Zhang
    • Xinyu Bai
    • Haopeng Chen
    • Hao Li
    • Yanjun Hong
    • Zhiyong Xie

  • PubMed: 41840625
  • DOI: 10.1186/s12951-026-04275-8

  3 Insights on

  • Improved Response to PD-1 Immunotherapy

  • Low evidence

  pflB plus anti-PD1 therapy markedly increased the infiltration of CD8⁺ CTL and NK cells, and enhanced their cytotoxicity compared to either monotherapy

  Effect

  Beneficial

  Effect size

  Large