Bifidobacterium Infantis Promotes FOSL1-Mediated Transcriptional Repression of VDR to Accelerate Autoimmune Pancreatitis Progression Through Activation of Oxidative Stress.
- 2026-01-23
- Inflammation 49(1)
- Jie Tang
- Qin Li
- Kai Li
- Dongyun Hang
- Danyin Gu
- Lingmei Feng
- Guoyu Chen
- Ming Xu
- PubMed: 41572095
- DOI: 10.1007/s10753-025-02368-4
- Low evidence
B. infantis accelerated pancreatitis in mice with mild AIP by activating pDCs... These data collectively suggest that B. infantis activates FOSL1 and inhibits VDR transcription... thereby exacerbating AIP.
- Effect
- Harmful
- Effect size
- Moderate