Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial.
- 2025-05-18
- RCT · n = 35
- Nutrients 17(10)
- Lucrezia Laterza
- Cesare Cremon
- Gaetano Coppola
- Carlo Romano Settanni
- Rossella Maresca
- Martina Strazzeri
- Eleonora Durini
- Valentina Petito
- Franco Scaldaferri
- Giorgio Gargari
- Diego Mora
- Elnaz Vojoudi Yazdi
- Chiara Marangelo
- Gianluca Ianiro
- Lorenza Putignani
- Maria Raffaella Barbaro
- Giovanni Marasco
- Giovanni Barbara
- Antonio Gasbarrini
- PubMed: 40431448
- DOI: 10.3390/nu17101708
- High evidence
- Rigorous Journal
Mean zonulin values showed a significant progressive reduction in the active group (-10.2 ng/mL at week 12, p = 0.0375; -19.5 ng/mL at week 16, p = 0.0002), with a significant difference between groups at week 16 in the per-protocol population (-19.01, p = 0.0053).
- Beneficial
- Moderate effect
- Significant