Bifidobacterium lactis BA05 and Improved Gut Barrier Function

• Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial.

  • 2025-05-18
  • RCT · n = 35
  • Nutrients 17(10)
  • • Lucrezia Laterza
    • Cesare Cremon
    • Gaetano Coppola
    • Carlo Romano Settanni
    • Rossella Maresca
    • Martina Strazzeri
    • Eleonora Durini
    • Valentina Petito
    • Franco Scaldaferri
    • Giorgio Gargari
    • Diego Mora
    • Elnaz Vojoudi Yazdi
    • Chiara Marangelo
    • Gianluca Ianiro
    • Lorenza Putignani
    • Maria Raffaella Barbaro
    • Giovanni Marasco
    • Giovanni Barbara
    • Antonio Gasbarrini

  • PubMed: 40431448
  • DOI: 10.3390/nu17101708

  2 Insights on

  • Improved Gut Barrier Function

  • High evidence
  • Rigorous Journal

  Mean zonulin values showed a significant progressive reduction in the active group (-10.2 ng/mL at week 12, p = 0.0375; -19.5 ng/mL at week 16, p = 0.0002), with a significant difference between groups at week 16 in the per-protocol population (-19.01, p = 0.0053).

  • Beneficial
  • Moderate effect
  • Significant