Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Bifidobacterium lactis BB-12 and Improved Intestinal Epithelial Integrity

Safety in these studies

Overall tolerabilityReported
While generally safe in healthy populations, rare adverse events (bacteremia, D-lactic acidosis, horizontal gene transfer) have been reported in immunocompromised or critically ill individuals, underscoring the need for individualized risk-benefit assessments and rigorous adverse-event surveillance.
from: Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Inte

1 of 1 paper

Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Intestinal, Neurologic, and Cardiovascular Health: a Narrative Review.
- 2026-11
- Review
- The Journal of nutritional biochemistry 157
- - Álvaro Vergara A Nieto
  - Andrés Halabi Diaz
  - Millaray Hernández Millán
  - Daniel Sagredo
  - Javier Arriagada Gacitua
- PubMed: 42177952
- DOI: 10.1016/j.jnutbio.2026.110424
10 Insights on
- Improved Intestinal Epithelial Integrity
- Low evidence
Probiotics such as Lactobacillus rhamnosus GG and Bifidobacterium lactis BB-12 reinforce epithelial integrity via upregulation of tight-junction proteins
Effect
Beneficial
Effect size
Small
Significant
Yes