Extremely oxygen-sensitive next-generation probiotics: can current microcomposite formulations ensure effective colonic delivery?
- 2026-01-22
- Review
- Microsystems & nanoengineering 12(1)
- L P Ta
- S Corrigan
- H Abeysekera
- R D Horniblow
- PubMed: 41571627
- DOI: 10.1038/s41378-025-01151-7
- Low evidence
Hydrated pectin- and gellan-based microcomposite systems, particularly when combined with xanthan gum or other polymers, exhibited the strongest oxygen-protection performance... Despite some microcomposite systems demonstrating potential for EOS colonic delivery, our findings highlight a critical gap in formulation science for these sensitive bioactives.
- Effect
- Neutral
- Effect size
- Small