Bifidobacterium lactis BI-04 and Improved Liver Function

• Harnessing a germ‑free mouse gut bioreactor for directed evolution of probiotics to combat non-alcoholic fatty liver disease.

  • 2026-02-24
  • Nature communications 17(1)
  • • Zhe Han
    • Zheng Sun
    • Xinlei Liu
    • Dongyu Zhen
    • Quan Guo
    • Leijie Zheng
    • Shuaiming Jiang
    • Zeng Zhang
    • Siyuan Shen
    • Jiachao Zhang

  • PubMed: 41735321
  • DOI: 10.1038/s41467-026-69823-0

  2 Insights on

  • Improved Liver Function

  • Moderate evidence
  • Rigorous Journal

  the adapted strain significantly improves bile-acid homeostasis, reduces hepatic steatosis, lowers inflammatory and lipid biomarkers, and enhances histological liver health compared to the parental strain.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes