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Bifidobacterium lactis UABla-12 and Reduced MAdCAM-1 Level

Doses used in studies
  • CFU single-dose: 10 billion (median 10 billion, IQR 10 billion–10 billion) — 1 study
Time to effect
Median: 2 weeks · IQR 2 weeks–2 weeks · Range 2 weeks–2 weeks — Reported in 1 of 1 study
Safety in these studies
1 of 1 paper

  • Probiotics, Anticipation Stress, and the Acute Immune Response to Night Shift.

    • 2021-01-28
    • RCT · n = 29
    • Frontiers in immunology 11
      • Nicholas P West
      • Lily Hughes
      • Rebecca Ramsey
      • Ping Zhang
      • Ping Zhang
      • Christopher J Martoni
      • Gregory J Leyer
      • Allan W Cripps
      • Amanda J Cox
    12 Insights on
    • High evidence
    • Adults

    The 14-day supplementation period that coincided with typical night-day sleep-wake cycles leading up to night shift (V1 to V2) was associated with significant changes in the placebo group in the concentration of serum ... MAdCAM-1 (p = 0.001) ... In contrast, probiotic supplementation moderated changes in these serum markers from V1 to V2. No significant interaction effects (time by group) were observed for the serum markers prior to and after night shift work following probiotic supplementation due to the substantial changes in the serum markers that occurred during the normal sleep period from V1 to V2.

    Effect
    Neutral
    Effect size
    Small
    Significant
    No
    Dose
    1 × 10^10 colony forming units (CFU)
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