Bifidobacterium lactis VK2 and Improved Bone Health

• Akkermansia muciniphila and osteoporosis: emerging role of gut microbiota in skeletal homeostasis.

  • 2025-09-15
  • Review
  • Frontiers in microbiology 16
  • • Yanlong Gong
    • Xin Ma
    • Jiumei Huang
    • Pengwei Zhang
    • Yunxiang Hai
    • Yongjia Song
    • Min Song
    • Yuanzhen Li
    • Haonan Wen
    • Wantao Dong

  • PubMed: 41030554
  • DOI: 10.3389/fmicb.2025.1665101

  1 Insight on

  • Improved Bone Health

  • Low evidence

  These substances boost Runx2-mediated osteoblast (OB) differentiation. They also suppress NF-κB-driven osteoclastogenesis... Findings on Akkermansia muciniphila and bone health are conflicting. Some clinical and animal studies link higher abundance to better bone mass, with depletion worsening OP.

  Effect

  Beneficial

  Effect size

  Small