Bifidobacterium lactis VK2 and Reduced Anticoagulation / Increased Warfarin Variability

• Exploring the complex relationship between vitamin K, gut microbiota, and warfarin variability in cardiac surgery patients.

  • 2023-08-17
  • Observational
  • International journal of surgery (London, England) 109(12)
  • • Ling Xue
    • Rajeev K Singla
    • Qiong Qin
    • Yinglong Ding
    • Linsheng Liu
    • Xiaoliang Ding
    • Wenhao Qu
    • Chenrong Huang
    • Zhenya Shen
    • Bairong Shen
    • Liyan Miao

  • PubMed: 37598356
  • DOI: 10.1097/js9.0000000000000673

  1 Insight on

  • Reduced Anticoagulation / Increased Warfarin Variability

  • Low evidence

  The results suggest that an increase in vitamin K concentration can decrease anticoagulation, and gut microbiota may influence warfarin anticoagulation through vitamin K2 synthesis.

  Effect

  Harmful

  Effect size

  Moderate