Bifidobacterium lactis and Improved Intestinal Metaplasia Regression

• Probiotics ameliorate H. pylori-associated gastric β-catenin and COX-2 carcinogenesis signaling by regulating miR-185.

  • 2025-06-03
  • RCT
  • Journal of biomedical science 32(1)
  • • Yao-Jong Yang
    • Chung-Tai Wu
    • Hsiu-Chi Cheng
    • Wei-Ying Chen
    • Joseph T Tseng
    • Wei-Lun Chang
    • Bor-Shyang Sheu

  • PubMed: 40462044
  • DOI: 10.1186/s12929-025-01149-3

  1 Insight on

  • Improved Intestinal Metaplasia Regression

  • High evidence
  • Clinical

  In the 6-month probiotic-treated patients had a significantly higher IM regression rate than controls (intention-to-treat: 37.5 vs 11.5%, OR: 4.60, 95% CI: 1.134-18.65, p = 0.025; per-protocol: 46.2 vs 17.6%, OR: 4.00, 95% CI: 0.923-17.33, p = 0.055).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes