Bifidobacterium longum BB536 and Improved Well-Being

• Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study.

  • 2025-04-10
  • Clinical Trial
  • Gut microbes reports 2(1)
  • • Riko Mishima
    • Ryuta Ejima
    • Satoshi Arai
    • Ayako Horigome
    • Eri Mitsuyama
    • Hiroki Kaneko
    • Kana Yamaguchi
    • Keita Kamezaki
    • Yuka Togashi
    • Kiyoshi Nakamura
    • Noriyuki Iwabuchi
    • Miyuki Tanaka
    • Toshitaka Odamaki
    • Shinji Fukuda
    • Yuji Naito

  • PubMed: 41909908
  • DOI: 10.1080/29933935.2025.2490092

  3 Insights on

  • Improved Well-Being

  • Moderate evidence

  Post-intervention, we observed an increase in bowel movement scores and improved life quality metrics, including both the WHO-HPQ absolute and relative presenteeism and the WHO-SUBI well-being score.

  Effect

  Beneficial

  Effect size

  Moderate