Bifidobacterium longum infantis M-63 and Improved Immunostimulatory Activity

• Role of 70 °C heating on immunostimulatory effects of probiotic bifidobacteria in infant formula.

  • 2026-01
  • Food research international (Ottawa, Ont.) 223
  • • Akira Sen
    • Sayaka Ishihara
    • Masahiro Ando
    • Hiroki Kaneko
    • Riko Mishima
    • Tatsuki Nishimura
    • Yukihiro Hishida
    • Miyuki Tanaka
    • Haruko Takeyama
    • Toshitaka Odamaki

  • PubMed: 41360542
  • DOI: 10.1016/j.foodres.2025.117846

  1 Insight on

  • Improved Immunostimulatory Activity

  • Low evidence

  The reduction in the immunostimulatory effect was less significant in bacterial cells heated at 70 °C for 1 min than in those heated at 90 °C for 15 min... These findings indicate that incorporating live bifidobacteria into infant formula as immunostimulatory ingredients is beneficial, even after the 70 °C preparation step

  Effect

  Beneficial

  Effect size

  Small