Bifidobacterium longum infantis M-63 and Increased Fecal Secretory IgA Levels

• Early Probiotic Supplementation of Healthy Term Infants with Bifidobacterium longum subsp. infantis M-63 Is Safe and Leads to the Development of Bifidobacterium-Predominant Gut Microbiota: A Double-Blind, Placebo-Controlled Trial

  • 2023-03-14
  • RCT · n = 110
  • Nutrients 15(6)
  • • A. Hiraku
    • Setsuko Nakata
    • Mai Murata
    • Chendong Xu
    • N. Mutoh
    • Satoshi Arai
    • T. Odamaki
    • N. Iwabuchi
    • Miyuki Tanaka
    • Takahisa Tsuno
    • Masahiko Nakamura

  • PubMed: 36986131
  • DOI: 10.3390/nu15061402

  18 Insights on

  • Increased Fecal Secretory IgA Levels

  • High evidence

  Supplementation with B. infantis M-63 led to increased levels of IgA in the stool at 1 month of age compared with the placebo group.

  Effect

  Beneficial

  Effect size

  Moderate