The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication
- 2011-10-11
- Clinical Trial
- Neurogastroenterology & Motility 23(12)
- P. Bercik
- A. Park
- D. Sinclair
- A. Khoshdel
- J. Lu
- X. Huang
- Y. Deng
- P. Blennerhassett
- M. Fahnestock
- D. Moine
- B. Berger
- J. Huizinga
- W. Kunze
- P. McLean
- G. Bergonzelli
- S. Collins
- Eduardo Verdu
- PubMed: 21988661
- DOI: 10.1111/j.1365-2982.2011.01796.x
- Low evidence
- Highly Cited
- Animal Study
- Clinical
Chronic colitis was associated with anxiety-like behavior, which was absent in previously vagotomized mice. B. longum normalized behavior but had no effect on MPO activity or histological scores.
- Effect
- Beneficial
- Effect size
- Moderate