Bifidobacterium longum R0175 and Improved Cognitive Function

Safety in these studies

Overall tolerabilityReported
While generally safe in healthy populations, rare adverse events (bacteremia, D-lactic acidosis, horizontal gene transfer) have been reported in immunocompromised or critically ill individuals, underscoring the need for individualized risk-benefit assessments and rigorous adverse-event surveillance.
from: Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Inte

1 of 1 paper

Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Intestinal, Neurologic, and Cardiovascular Health: a Narrative Review.

2026-11
Review
The Journal of nutritional biochemistry 157
- Álvaro Vergara A Nieto
- Andrés Halabi Diaz
- Millaray Hernández Millán
- Daniel Sagredo
- Javier Arriagada Gacitua

PubMed: 42177952
DOI: 10.1016/j.jnutbio.2026.110424

10 Insights on

Improved Cognitive Function

Low evidence

Psychobiotic strains (e.g., L. rhamnosus JB-1, B. longum 1714, L. helveticus R0052 + B. longum R0175) modulate neurotransmitter synthesis (GABA, serotonin), dampen HPA-axis hyperactivity, and reduce neuroinflammation, yielding improvements in ... cognitive function

Effect: Beneficial
Effect size: Small
Significant: Yes