Bifidobacterium longum SD-5588 and Reduced Hepatic Lipid Accumulation

• Probiotics and Non-Alcoholic Fatty Liver Disease: Unveiling the Mechanisms of Lactobacillus plantarum and Bifidobacterium bifidum in Modulating Lipid Metabolism, Inflammation, and Intestinal Barrier Integrity.

  • 2024-09-21
  • Review
  • Foods (Basel, Switzerland) 13(18)
  • • Jing Lu
    • Dilireba Shataer
    • Huizhen Yan
    • Xiaoxiao Dong
    • Minwei Zhang
    • Yanan Qin
    • Jie Cui
    • Liang Wang

  • PubMed: 39335920
  • DOI: 10.3390/foods13182992

  6 Insights on

  • Reduced Hepatic Lipid Accumulation

  • Low evidence

  These probiotics manipulate lipid synthesis genes and phosphorylated proteins through pathways such as the AMPK/Nrf2, LPS-TLR4-NF-κB, AMPKα/PGC-1α, SREBP-1/FAS, and SREBP-1/ACC signaling pathways to reduce hepatic lipid accumulation and oxidative stress, key components of NAFLD progression.

  Effect

  Beneficial

  Effect size

  Moderate