Bifidobacterium longum subsp. longum and Improved Reproductive Health

• Protective effects of Bifidobacterium longum subsp. longum BL21 against cyclophosphamide-induced reproductive dysfunction in zebrafish.

  • 2025-04-18
  • Scientific reports 15(1)
  • • Yao Dong
    • Jiazhi Zhou
    • Hairui Tian
    • Zhonghui Gai
    • Kang Zou
    • Quanwei Wei
    • Mei Han

  • PubMed: 40251294
  • DOI: 10.1038/s41598-025-97721-w

  1 Insight on

  • Improved Reproductive Health

  • Low evidence
  • Rigorous Journal
  • Animal Study

  BL21 demonstrated significant therapeutic potential in treating reproductive dysfunction in zebrafish... The probiotic treatment notably improved testicular weight (p < 0.01) and sperm count and vitality (p < 0.001) compared to the cyclophosphamide-induced model control... BL21 intervention led to a marked increase in chasing behavior and sex hormone levels... [and] significantly reduced sperm DNA fragmentation (p < 0.001) and increased the expression of genes crucial for spermatogenesis and testicular function

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes