Bifidobacterium longum subsp. longum and Reduced Cancer Progression

• Bifidobacterium longum subsp. longum XZ01 delays the progression of colon cancer in mice through the interaction between the microbial spatial distribution and tumour immunity.

  • 2025-03
  • International immunopharmacology 150
  • • Ying Chen
    • Jinyun Wu
    • Kaiwei Cai
    • Xiaoyi Xiao
    • Ye Chen
    • Xingyuan Zhang
    • Song Deng
    • Chaoying Pei
    • Yanlong Chen
    • Zhiyong Xie
    • Pei Li
    • Qiongfeng Liao

  • PubMed: 39955918
  • DOI: 10.1016/j.intimp.2025.114283

  1 Insight on

  • Reduced Cancer Progression

  • Low evidence

  Bifidobacterium longum subsp. longum (XZ01) to intervene in a colon cancer mouse model and found that its mechanism may be related to the interaction between the spatial distribution of microorganisms and tumour immunity... XZ01 directly regulates the polarisation of M0 macrophages towards the M1 phenotype by upregulating IFN-γ, thus activating tumour immunity to inhibit the growth of tumour cells.

  Effect

  Beneficial

  Effect size

  Moderate