Bifidobacterium longum and Maintained Safety with Repeated Oral Exposure

• A 90-day oral toxicity study of heat-treated Bifidobacterium longum CECT 7347 (ES1 HT) Postbiotic in rats.

  • 2026-06
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 212
  • • Jay S Petrick
    • Roger Mariné-Casadó
    • Richard Day
    • Patricia Martorell
    • Carolina C Venditti
    • Empar Chenoll

  • PubMed: 41724422
  • DOI: 10.1016/j.fct.2026.116025

  2 Insights on

  • Maintained Safety with Repeated Oral Exposure

  • Low evidence
  • Animal Study

  Based on the observed results, the NOAEL for heat-treated B. longum CECT 7347 (ES1 HT) in male and female Wistar rats following 90-days of repeated dose oral exposure was 5 x 10¹⁰ CFUeq/kg (1000 mg/kg limit dose) per day.

  Effect

  Beneficial

  Effect size

  Small