Clostridium butyricum and Reduced Total Bilirubin Level

• Efficacy of Clostridium butyricum Supplementation Combined with Phototherapy for Neonatal Hyperbilirubinemia: A Systematic Review and Meta-Analysis.

  • 2025-06-20
  • Review
  • Microorganisms 13(7)
  • • Eun-Jin Kim
    • Ho-Yeon Go
    • Hyun-Kyung Sung

  • PubMed: 40731950
  • DOI: 10.3390/microorganisms13071441

  3 Insights on

  • Reduced Total Bilirubin Level

  • Low evidence
  • Infants

  Compared to phototherapy alone, C. butyricum supplementation significantly reduced total bilirubin (SMD = -1.54, 95% CI: -2.21 to -0.86)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes