Lacticaseibacillus casei R0215 and Reduced Crying in Infants

• Effects of a nine-strain bacterial synbiotic compared to simethicone in colicky babies - an open-label randomised study.

  • 2021-06-15
  • RCT · n = 87
  • Beneficial microbes 12(3)
  • • J Piątek
    • M Bernatek
    • H Krauss
    • M Wojciechowska
    • Z Chęcińska-Maciejewska
    • P Kaczmarek
    • H Sommermeyer

  • PubMed: 33765904
  • DOI: 10.3920/bm2020.0160

  4 Insights on

  • Reduced Crying in Infants

  • High evidence
  • Rigorous Journal

  Significantly higher responder rates (effect ≥50% reduction from baseline) of the multi-strain synbiotic compared to simethicone were found for the measures 'crying days last 3 weeks' (72% vs 18%, P<0.0001) and 'average evening crying duration last 3 weeks' (85% vs 39%, P=0.0001).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes