Lacticaseibacillus casei and Increased CD4+ T Cell Count

• Immune effects of Lactobacillus casei Shirota in treated HIV-infected patients with poor CD4+ T-cell recovery.

  • 2020-03-01
  • RCT · n = 48
  • AIDS (London, England) 34(3)
  • • Simone de Barros Tenore
    • Vivian Iida Avelino-Silva
    • Priscilla Ramos Costa
    • Lucas M Franco
    • Ester Cerdeira Sabino
    • Jorge Kalil
    • Natalia Barros Cerqueira
    • Zelinda Nakagawa
    • Esper Georges Kallas

  • PubMed: 31714353
  • DOI: 10.1097/qad.0000000000002420

  5 Insights on

  • Increased CD4+ T Cell Count

  • High evidence
  • Clinical

  At week 6, the increment in CD4+ T-cell count was 17 cells/μl ... in the active intervention arm and 4 cells/μl ... in the placebo arm (P = 0.291); at week 12, the change in CD4+ T-cell count was 8 cells//μl ... in the active arm and 10 cells//μl ... among participants allocated to placebo (P = 0.495).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  daily oral use