Lacticaseibacillus casei and Reduced Interleukin-4 Levels

Doses used in studies

cells/day: 13 billion (median 13 billion, IQR 13 billion–13 billion) — 1 study

Time to effect

Median: 3.3 months · IQR 3.3 months–3.3 months · Range 3.3 months–3.3 months — Reported in 1 of 1 study

1 of 1 paper

Immune Response of Healthy Adults to the Ingested Probiotic Lactobacillus casei Shirota.

2016-12
Clinical Trial
Scandinavian journal of immunology 84(6)
- L S Harbige
- E Pinto
- J Allgrove
- L V Thomas

PubMed: 27718254
DOI: 10.1111/sji.12495

10 Insights on

Reduced Interleukin-4 Levels

Moderate evidence
Adults

Intracellular staining of IL-4 in ex vivo unstimulated and PMA-/ionomycin-stimulated CD3+ β7+ integrin blood cells was significantly lower at weeks 10 and 14

Effect: Beneficial
Effect size: Small
Significant: Yes
Dose: 1.3 × 10^10 live cells/day