Lacticaseibacillus paracasei Lpc-37 and No Reduction in Stress or Anxiety

• Efficacy and safety of Lacticaseibacillus paracasei Lpc-37® in students facing examination stress: A randomized, triple-blind, placebo-controlled clinical trial (the ChillEx study).

  • 2023-10
  • RCT
  • Brain, behavior, & immunity - health 32
  • • Sanna M Mäkelä
    • Síle M Griffin
    • Jenni Reimari
    • Kara C Evans
    • Ashley A Hibberd
    • Nicolas Yeung
    • Alvin Ibarra
    • Jouni Junnila
    • Jari Turunen
    • Ronnie Beboso
    • Balgit Chhokar
    • Timothy G Dinan
    • John Cryan
    • Elaine Patterson

  • PubMed: 37662485
  • DOI: 10.1016/j.bbih.2023.100673

  4 Insights on

  • No Reduction in Stress or Anxiety

  • High evidence

  There was no difference between Lpc-37 and placebo groups in the change of STAI-state score (estimate 1.03; 95% confidence interval [CI]: -1.62, 3.67; p = 0.446).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No