Lactiplantibacillus plantarum LP-01 and Increased Immune Marker Activation

• Self-aggregating Lactiplantibacillus plantarum enhances type-I interferon responses via the cytosolic sensors NOD2 and cGAS.

  • 2026-01-28
  • Gut microbes 18(1)
  • • Selvin Solis
    • Elaina M Maldonado
    • Subhankar Mukhopadhyay
    • Gwénaël Jan
    • José María Landete
    • Carlos Maluquer de Motes
    • Jorge Gutierrez-Merino

  • PubMed: 41605865
  • DOI: 10.1080/19490976.2026.2615490

  3 Insights on

  • Increased Immune Marker Activation

  • Low evidence

  these bacteria interact very intimately with macrophages ... leading to significant production of type I interferon (IFN-I) cytokines

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes