Lactiplantibacillus plantarum LP-01 and Reduced Proinflammatory Signaling

• Vaginal-Derived Potential Probiotics and Their Postbiotics Alleviate Aerobic Vaginitis via Suppressing TLR4/MyD88/NF-κB Signalling Pathway and Potentially Enhancing Vaginal Barrier.

  • 2026-03
  • Microbial biotechnology 19(3)
  • • Meiyun Tian
    • Xinyi Zhang
    • Xuan Xu
    • Xia He
    • Xiaoyun Wu
    • Jing Wei
    • Buzhen Tan
    • Tingtao Chen

  • PubMed: 41807990
  • DOI: 10.1111/1751-7915.70327

  4 Insights on

  • Reduced Proinflammatory Signaling

  • Low evidence
  • Animal Study

  the postbiotics effectively mirrored the mechanisms of their live counterparts by downregulating the TLR4/MyD88/NF-κB pathway (p < 0.01)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes