Lactobacillus acidophilus HA-122 and Improved Barrier Integrity

• Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma.

  • 2025-04-07
  • Nature communications 16(1)
  • • Jiayu Zhang
    • Jinneng Yang
    • Jinyan Luo
    • Weili Wu
    • Haidan Luo
    • Wenxia Wei
    • Haimei Lyu
    • Yuzhi Wang
    • Hairong Yi
    • Yijing Zhang
    • Zongmin Fan
    • Haiwen Lyu
    • Vishnu Priya Kanakaveti
    • Baifu Qin
    • Ping Yuan
    • Runxiang Yang
    • Haipeng Zhang
    • Tao Zuo
    • Dean W Felsher
    • Mong-Hong Lee
    • Kai Li

  • PubMed: 40195307
  • DOI: 10.1038/s41467-025-58407-z

  3 Insights on

  • Improved Barrier Integrity

  • Moderate evidence
  • Rigorous Journal

  L. acidophilus supplementation confers sensitivity to VSVΔ51 through restoring gut barrier integrity and microbiota homeostasis destroyed by VSVΔ51.

  Effect

  Beneficial

  Effect size

  Moderate