Lactobacillus acidophilus HA-122 and Reduced Chemotherapy-Induced Diarrhea

• Efficacy and safety of probiotics in preventing chemotherapy-related diarrhea in patients with colorectal cancer: A systematic review and meta-analysis based on 18 randomized trials.

  • 2025-07-04
  • Meta-Analysis · n = 1,526
  • Medicine 104(27)
  • • Meilin Yang
    • Lu Wang
    • Chu Luo
    • Jiarong Shang
    • Xia Zheng
    • Jun Qian
    • Ran Yang

  • PubMed: 40629588
  • DOI: 10.1097/md.0000000000043126

  4 Insights on

  • Reduced Chemotherapy-Induced Diarrhea

  • High evidence

  Meta-analysis demonstrated that probiotics significantly reduced the incidence of diarrhea following chemotherapy in the probiotic group compared to the control group (risk ratio, 0.51; 95% confidence interval: [0.40-0.64]; P = .029).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• The Role of Microbiome and Probiotics in Chemo-Radiotherapy-Induced Diarrhea: A Narrative Review of the Current Evidence.

  • 2024-10
  • Review
  • Cancer reports (Hoboken, N.J.) 7(10)
  • • Sanaz Khorashadizadeh
    • Sara Abbasifar
    • Mohammad Yousefi
    • Farzad Fayedeh
    • AmirAli Moodi Ghalibaf

  • PubMed: 39410854
  • DOI: 10.1002/cnr2.70029

  4 Insights on

  • Reduced Chemotherapy-Induced Diarrhea

  • Low evidence

  Probiotic supplements have been found to be able to reverse the intestinal damage caused by chemo-radiation therapy by promoting the growth of crypt and villi and reducing inflammatory pathways.

  Effect

  Beneficial

  Effect size

  Moderate