Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Severity

Research synthesisModerate evidenceModerate effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all reported beneficial moderate-sized effects of Lactobacillus acidophilus L-92 on improving atopic dermatitis severity. Three of four studies found statistically significant reductions in SCORAD and other severity indices, with moderate effect sizes observed in both children (aged 1 month to 10 years) and adults. The most studied dose was 20 mg L-92/day in one RCT, though dosing was not consistently reported across studies.

Effective dose range: 20 mg L-92/day
Studied populations: young children with atopic dermatitis and food allergy; adult atopic dermatitis patients

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary.

Generated May 12, 2026

Doses used in studies

CFU/day: 1 (median 1, IQR 1–1) — 1 study
mg/day: 20 (median 20, IQR 20–20) — 1 study

Safety in these studies

Overall tolerabilityReported
No adverse events were reported during the study period.
from: Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with a
Overall tolerabilityReported
No abstract text explicitly mentions adverse events, side effects, or tolerability. The study only reports efficacy outcomes (SCORAD, TARC, total IgE) without any mention of safety findings.
from: Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis conco

4 of 4 papersPopulation:

Lactobacillus GG and other probiotics in pediatric food allergy treatment: a network meta-analysis.
- 2025-06-03
- Systematic Review · n = 502
- Frontiers in nutrition 12
- - Li Xiaohua
  - Du Yiting
  - Li Qin
  - Zhai Yang
  - Wu Shumao
  - Peng Li
  - Pan Yi
  - Chen Lingmei
  - Liao Wenge
  - Li Maoxia
- PubMed: 40529417
- DOI: 10.3389/fnut.2025.1565436
7 Insights on
- Improved Atopic Dermatitis Severity
- High evidence
Lactobacillus GG (LGG) was identified as the most effective in reducing Scoring Atopic Dermatitis (SCORAD) scores (SMD = -4.24, 95% CI [-7.12, -1.36]; p < 0.05) and improving quality of life.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy
- 2019-04
- RCT · n = 59
- Asia Pacific Allergy 9(2)
- - Joan Nakata
  - Tatsuhiko Hirota
  - Harue Umemura
  - T. Nakagawa
  - N. Kando
  - M. Futamura
  - Yasunori Nakamura
  - Komei Ito
- PubMed: 31089460
- DOI: 10.5415/apallergy.2019.9.e18
7 Insights on
- Improved Atopic Dermatitis Severity
- High evidence
- Rigorous Journal
- Clinical
After 24 weeks of intervention, a significant decrease in SCORAD was observed only in the L-92 group when compared with the baseline values.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
20 mg L-92/day
Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis.
- 2016-07
- RCT · n = 50
- Journal of Dairy Science 99(7)
- - Kozo Yamamoto
  - K. Yokoyama
  - Takehisa Matsukawa
  - Sayaka Kato
  - S. Kato
  - Kazuhisa Yamada
  - Tatsuhiko Hirota
- PubMed: 27108169
- DOI: 10.3168/jds.2015-10605
18 Insights on
- Improved Atopic Dermatitis Severity
- High evidence
- Rigorous Journal
- Clinical
Compared with the placebo group, the L-92 group showed significant decreases in investigator global assessment, eczema area and severity index, and scoring atopic dermatitis.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
heat-killed and dried L-92 daily
Microbiome and Skin Health: A Systematic Review of Nutraceutical Interventions, Disease Severity, Inflammation, and Gut Microbiota.
- 2025-12-26
- Review
- Microorganisms 14(1)
- - Alia Ashkanani
  - Ghalya Ashkanani
  - Mahmoud Yousef
  - Mlaak Rob
  - Maha Al-Marri
  - Nesha Naseem
  - Sa'ad Laws
  - Ali Chaari
- PubMed: 41597583
- DOI: 10.3390/microorganisms14010063
6 Insights on
- Improved Atopic Dermatitis Severity
- Low evidence
The SCORAD of the treated group was substantially lower than that of the placebo group in 30 of the 47 trials on atopic dermatitis.
Effect
Beneficial
Effect size
Moderate

Lactobacillus acidophilus L-92 and Improved Atopic Dermatitis Severity

Lactobacillus GG and other probiotics in pediatric food allergy treatment: a network meta-analysis.

Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy

Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis.

Microbiome and Skin Health: A Systematic Review of Nutraceutical Interventions, Disease Severity, Inflammation, and Gut Microbiota.