Research synthesisModerate evidenceModerate effect4 studies · 4 beneficial · 0 neutral · 0 harmful
Across 4 studies, all reported beneficial moderate-sized effects of Lactobacillus acidophilus L-92 on improving atopic dermatitis severity. Three of the 4 studies found statistically significant improvements, with effects typically moderate in magnitude. The most-studied population includes young children with atopic dermatitis and food allergy, as well as adult patients, with doses including 20 mg L-92/day or heat-killed dried preparations, though study durations were not consistently reported.
- Effective dose range: 20 mg L-92/day or heat-killed dried L-92 daily
- Studied populations: Young children with atopic dermatitis and diagnosed or suspected food allergy; adult atopic dermatitis patients
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Study durations were not consistently reported, making it difficult to estimate how long supplementation is needed for benefit.
Generated Jul 11, 2026