Lactobacillus acidophilus L-92 and Increased Transforming Growth Factor-β Levels

• Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis.

  • 2016-07
  • RCT · n = 50
  • Journal of Dairy Science 99(7)
  • • Kozo Yamamoto
    • K. Yokoyama
    • Takehisa Matsukawa
    • Sayaka Kato
    • S. Kato
    • Kazuhisa Yamada
    • Tatsuhiko Hirota

  • PubMed: 27108169
  • DOI: 10.3168/jds.2015-10605

  18 Insights on

  • Increased Transforming Growth Factor-β Levels

  • High evidence
  • Rigorous Journal
  • Clinical

  Sixteen weeks after the study commenced, a significant increase in transforming growth factor-β was observed in the L-92 group compared with the placebo group.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  heat-killed and dried L-92 daily

• Effects of Oral Administration of Lactobacillus acidophilus L-92 on the Symptoms and Serum Cytokines of Atopic Dermatitis in Japanese Adults: A Double-Blind, Randomized, Clinical Trial

  • 2015-04-16
  • RCT · n = 49
  • International Archives of Allergy and Immunology 165(4)
  • • Y. Inoue
    • T. Kambara
    • Naoko Murata
    • J. Komori-Yamaguchi
    • S. Matsukura
    • Yukitoshi Takahashi
    • Z. Ikezawa
    • M. Aihara

  • PubMed: 25660281
  • DOI: 10.1159/000369806

  3 Insights on

  • Increased Transforming Growth Factor-β Levels

  • High evidence
  • Clinical

  and increased ratios of change for serum TGF-β (p = 0.03).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes