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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lactobacillus acidophilus L-92 and Reduced SCORAD Index

Doses used in studies

mg/day: 20 (median 20, IQR 20–20) — 1 study

Safety in these studies

Overall tolerabilityReported
No abstract text explicitly mentions adverse events, side effects, or tolerability. The study only reports efficacy outcomes (SCORAD, TARC, total IgE) without any mention of safety findings.
from: Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis conco

2 of 2 papersPopulation:

Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy
- 2019-04
- RCT · n = 59
- Asia Pacific Allergy 9(2)
- - Joan Nakata
  - Tatsuhiko Hirota
  - Harue Umemura
  - T. Nakagawa
  - N. Kando
  - M. Futamura
  - Yasunori Nakamura
  - Komei Ito
- PubMed: 31089460
- DOI: 10.5415/apallergy.2019.9.e18
7 Insights on
- Reduced SCORAD Index
- High evidence
- Rigorous Journal
- Clinical
After 24 weeks of intervention, a significant decrease in SCORAD was observed only in the L-92 group when compared with the baseline values.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
20 mg L-92/day
Impact of Probiotics on Atopic Dermatitis in Pediatric Patients: A Systematic Review and Meta-Analysis.
- 2025-11-24
- Meta-Analysis
- Medicina (Kaunas, Lithuania) 61(12)
- - Ritu Gaikwad
  - Soham Kondle
  - Sean Chang
  - Chris Barnes
  - Rohan Kubba
  - Christopher Lane
  - Snigdha Uppu
  - Eldo Frezza
- PubMed: 41470092
- DOI: 10.3390/medicina61122090
5 Insights on
- Reduced SCORAD Index
- High evidence
Of 25 studies extracted, 14 RCTs evaluated the effects of probiotics on atopic dermatitis using SCORAD scores. Eleven showed significant reductions in SCORAD indices.
Effect
Beneficial
Effect size
Moderate
Significant
Yes