Lactobacillus acidophilus La-14 and Reduced Bacterial Vaginosis Severity

• Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 Attenuate Gardnerella vaginalis-Infected Bacterial Vaginosis in Mice

  • 2017-05-23
  • Clinical Trial
  • Nutrients 9(6)
  • • Se-Eun Jang
    • Jin-Ju Jeong
    • Su-Young Choi
    • Hyun-Jee Kim
    • M. Han
    • Dong-Hyun Kim

  • PubMed: 28545241
  • DOI: 10.3390/nu9060531

  5 Insights on

  • Reduced Bacterial Vaginosis Severity

  • Low evidence
  • Animal Study

  Oral or intravaginal administration of L1, L2, or PM significantly inhibited GV-induced epithelial cell disruption, myeloperoxidase activity, NF-κB activation, and IL-1β and TNF-α expression (p < 0.05). Administration of these probiotics also inhibited IL-17 and RORγt expression but increased IL-10 and Foxp3 expression. Of these probiotics, L2 most effectively attenuated GV-induced BV, followed by L1 and PM.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes