Lactobacillus acidophilus La-14 and Reduced Hospital-acquired Infections

• Probiotics in the ICU: a scoping review of evidence for infection prevention.

  • 2026-01-05
  • Review · n = 500
  • Journal of translational medicine 24(1)
  • • Lulu Lou
    • Tianyu Liang
    • Maomao Lv

  • PubMed: 41491715
  • DOI: 10.1186/s12967-025-07637-2

  1 Insight on

  • Reduced Hospital-acquired Infections

  • High evidence

  Multi-strain preparations containing Lactobacillus acidophilus LA-5 (evaluated in four publications from two RCTs) were most consistently associated with benefit. All five studies using both intervention duration ≥ 14 days and dosage ≥ 5 × 10⁹ CFU/day reported significant reductions in at least one ICU-AI (100%; Fisher exact p = 0.007)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes