Lactobacillus acidophilus LA1 and Reduced Epithelial Permeability

• Lactobacillus acidophilus inhibits the TNF-α-induced increase in intestinal epithelial tight junction permeability via a TLR-2 and PI3K-dependent inhibition of NF-κB activation.

  • 2024-07-16
  • Frontiers in immunology 15
  • • Mohammad Haque
    • Lauren Kaminsky
    • Raz Abdulqadir
    • Jessica Engers
    • Evgeny Kovtunov
    • Manmeet Rawat
    • Rana Al-Sadi
    • Thomas Y Ma

  • PubMed: 39081324
  • DOI: 10.3389/fimmu.2024.1348010

  1 Insight on

  • Reduced Epithelial Permeability

  • Low evidence

  Pre-treatment of filter-grown Caco-2 monolayers with LA1 prevented the TNF-α-induced increase in intestinal epithelial TJ permeability

  Effect

  Beneficial

  Effect size

  Moderate