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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lactobacillus acidophilus NCFM and Increased Responder Rate

Doses used in studies

CFU/day: 1 billion (median 1 billion, IQR 1 billion–1 billion) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
The use of L. acidophilus NCFM was safe for this population.
from: Lactobacillus acidophilus for infant colic and microbiota modulation: a randomized clinica

1 of 1 paper

Lactobacillus acidophilus for infant colic and microbiota modulation: a randomized clinical trial.
- 2026-04-18
- RCT · n = 60
- BMC pediatrics 26(1)
- - Sáskia Ribeiro Vaz
  - Marise Helena Cardoso Tofoli
  - Melissa Ameloti Gomes Avelino
  - João Felipe Mota
  - Humberto Bezerra de Araujo Filho
  - Paulo Sucasas da Costa
- PubMed: 41998618
- DOI: 10.1186/s12887-026-06883-7
4 Insights on
- Increased Responder Rate
- High evidence
- Clinical
A higher responder rate was observed in the intervention group at Day 14 in exploratory analyses (p=0.045); however, this result was attenuated after correction for multiple comparisons.
Effect
Neutral
Effect size
Small
Significant
No
Dose
5 drops (1×10^9 CFU) daily for 28 days