Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short‐chain fatty acids metabolism and GPR41/43 expression in β‐lactoglobulin–sensitized mice
- 2019-07-29
- Clinical Trial
- Microbiology and Immunology 63(8)
- Jun-Juan Wang
- Qi-Min Zhang
- Wei-wei Ni
- Xin Zhang
- Ying Li
- Ai-Li Li
- P. Du
- Chun Li
- Su-Su Yu
- PubMed: 31218724
- DOI: 10.1111/1348-0421.12723
- Low evidence
- Animal Study
Further analysis revealed that the GPR41 and GPR43 messenger RNA expression both positively correlated with the serum concentrations of transforming growth factor-β and IFN-γ (p < .05), but negatively with the serum concentrations of IL-17, IL-4, and IL-6 in the L. acidophilus-treated group compared with the allergic group (p < .05). These results suggested that L. acidophilus protected against the development of allergic inflammation by improving the intestinal flora, as well as upregulating SCFAs and their receptors GPR41/43.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes