Microbiome and metabolome explain the high-fat diet-induced diabetes development and diabetes resistance in Guizhou mini-pigs.
- 2025-04-09
- Frontiers in microbiology 16
- Yanjun Wu
- Jiayuan Mo
- Qianguang Wang
- Jialong Li
- Jia Wei
- Nuo Zhang
- Yuanqiu Dong
- Xiang Zhu
- Taofeng Lu
- Sicheng Huang
- PubMed: 40291804
- DOI: 10.3389/fmicb.2025.1555069
- Low evidence
Key findings demonstrated anti-DM group parameters-including metabolic indices (fasting blood glucose, insulin levels, HbA1c, IVGTT), histopathology (HE-stained pancreatic/hepatic tissues), microbial profiles (structural, compositional, functional), and metabolomic signatures-occupied intermediate positions between CTR and DM groups. Network analyses revealed: (1) Lactobacillus, L. amylovorus, fingolimod, polyoxyethylene sorbitan monooleate, thiamine, and atrazine in HFD-associated networks
- Effect
- Harmful
- Effect size
- Moderate