Lactobacillus amylovorus and Improved Antiviral Immune Response

• A strain of Lactobacillus plantarum from piglet intestines enhances the anti-PoRV effect via the STING-IFN-I pathway.

  • 2025-05-03
  • BMC veterinary research 21(1)
  • • Anqi Sun
    • Xin Shan
    • Ruihan Liu
    • Zhengxu Tang
    • Jingshu Huang
    • Shihan Zhang
    • Lihong Bian
    • Yumeng Shi
    • Zixuan Liu
    • Jingtao Hu
    • Chunfeng Wang

  • PubMed: 40319282
  • DOI: 10.1186/s12917-025-04766-0

  3 Insights on

  • Improved Antiviral Immune Response

  • Low evidence
  • Animal Study

  Mechanistic investigations identified STING-IRF3 pathway activation as the pivotal antiviral mechanism. Both phosphorylation of STING and IRF3 in LP1-treated IPEC-J2 cells accompanied by upregulated transcription and secretion of IFN-β and interferon-stimulated genes (ISGs).

  Effect

  Beneficial

  Effect size

  Moderate