Lactobacillus amylovorus KU4 inhibits adipocyte senescence in aged mice through necdin regulation of p53 activity.
- 2025-09-03
- Aging 17(9)
- Garam Yang
- Eunjeong Hong
- Hyuno Kang
- Sejong Oh
- Eungseok Kim
- PubMed: 40906540
- DOI: 10.18632/aging.206314
- Low evidence
- Animal Study
ex vivo NDN silencing in the AT of D-galactose-induced aging mice abolished LKU4 protection against p53-induced adipose senescence, reducing adipogenesis and mitochondrial dysfunction in primary adipocytes.
- Effect
- Beneficial
- Effect size
- Moderate