Lactobacillus amylovorus and Increased Intestinal Stem Cell Proliferation

• Breed-Driven Microbiome Heterogeneity Regulates Intestinal Stem Cell Proliferation via Lactobacillus-Lactate-GPR81 Signaling.

  • 2024-06-27
  • Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11(33)
  • • Haiqin Wu
    • Chunlong Mu
    • Xuan Li
    • Wenlu Fan
    • Le Shen
    • Weiyun Zhu

  • PubMed: 38937989
  • DOI: 10.1002/advs.202400058

  3 Insights on

  • Increased Intestinal Stem Cell Proliferation

  • Low evidence
  • Animal Study

  live L. amylovorus and its metabolite lactate promote intestinal organoid growth... L. amylovorus and lactate activate Wnt/β-catenin signaling in a GPR81-dependent manner to promote ISC-mediated epithelial proliferation

  Effect

  Beneficial

  Effect size

  Moderate