Limosilactobacillus mucosae and Lactobacillus amylovorus Protect Against Experimental Colitis via Upregulation of Colonic 5-Hydroxytryptamine Receptor 4 and Transforming Growth Factor-β2.
- 2023-08
- The Journal of nutrition 153(8)
- Youling Hao
- Lili Jiang
- Dandan Han
- Dayong Si
- Zhiyuan Sun
- Zhenlong Wu
- Zhaolai Dai
- PubMed: 37356501
- DOI: 10.1016/j.tjnut.2023.06.031
- Low evidence
- Animal Study
Compared with mice in the DSS group, mice receiving DSS + LM or DSS + LA treatment had lower (P < 0.05) colonic mRNA expression of proinflammatory cytokines. DSS + LM treatment had lower mRNA expression of Il1b, Tnfa, and Ccl3... and greater expression of Tgfb2 and Htr4 in the colon... LM was more effective than LA in alleviating DSS-induced colonic inflammation.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes