Lactobacillus amylovorus Inhibits the TLR4 Inflammatory Signaling Triggered by Enterotoxigenic Escherichia coli via Modulation of the Negative Regulators and Involvement of TLR2 in Intestinal Caco-2 Cells and Pig Explants
- 2014-04-14
- PLoS ONE 9(4)
- A. Finamore
- Marianna Roselli
- Ambra Imbinto
- Julie Seeboth
- I. Oswald
- E. Mengheri
- PubMed: 24733511
- DOI: 10.1371/journal.pone.0094891
- Moderate evidence
- Highly Cited
- Rigorous Journal
- Mixed
L. amylovorus and its cell free supernatant suppress the activation of the different steps of TLR4 signaling... by inhibiting the ETEC induced increase in the level of TLR4 and MyD88... as well as the over-production of inflammatory cytokines IL-8 and IL-1β.
- Effect
- Beneficial
- Effect size
- Moderate