Lactobacillus amylovorus and Reduced Senescence-Associated Secretory Phenotype

• Lactobacillus amylovorus KU4 inhibits adipocyte senescence in aged mice through necdin regulation of p53 activity.

  • 2025-09-03
  • Aging 17(9)
  • • Garam Yang
    • Eunjeong Hong
    • Hyuno Kang
    • Sejong Oh
    • Eungseok Kim

  • PubMed: 40906540
  • DOI: 10.18632/aging.206314

  4 Insights on

  • Reduced Senescence-Associated Secretory Phenotype

  • Low evidence
  • Animal Study

  Both LKU4 and NDN consistently reduced the senescence-associated secretory phenotype (SASP) in the AT of aged mice and senescent 3T3-L1 adipocytes.

  Effect

  Beneficial

  Effect size

  Moderate