Lactobacillus brevis Lbr-35 and Restored Neurodegeneration-Associated Metabolic Alterations

• A rationally designed microbial consortium modulates neurodegeneration in a Drosophila melanogaster model of Parkinson's disease.

  • 2025-09-24
  • NPJ biofilms and microbiomes 11(1)
  • • Aline Ovalle
    • Estefanía López
    • Jimena Sierralta
    • Nuria Paricio
    • Daniel Garrido

  • PubMed: 40993130
  • DOI: 10.1038/s41522-025-00797-5

  3 Insights on

  • Restored Neurodegeneration-Associated Metabolic Alterations

  • Low evidence
  • Animal Study

  Head metabolomics revealed partial restoration of PD-associated alterations in energy balance, amino acid and neurotransmitter metabolism, and disease-related biomarkers.

  Effect

  Beneficial

  Effect size

  Moderate